Imad Shams Ph.D.

    Senior Researcher
    Office: Multi-Purpose Building, Room 231| Phone: 972-4-8240-591 | Fax: 972-4-8288-235
    Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
    Subject: Evolution under hypoxic stress: physiological and molecular mechanisms developed by Spalax to tolerate hypoxia and cancer
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    Research Interests

    •  Blind subterranean mole rat, Spalax is a wild mammal that evolved an outstanding ability to tolerate hypoxic/hypercapnic conditions in dark underground sealed burrows habitat.
    •  Our main goal is to explore the unique molecular mechanisms standing behind tolerance to extreme hypoxia, and insusceptibility to cancer in this unique mammal.

    Selected Publications 

    Band M, Shams I, Joel A, and Avivi A. (2008) Cloning and in vivo expression of vascular endothelial growth factor receptor 2 (Flk1) in the naturally hypoxia-tolerant subterranean mole rat. FASEB J. 22(1):105-112.

    Shams I, Rohmann E, Eswarakumar VP, Lew E, Yuzawa S, Wollnik B, Schlessinger J,  and Lax I. (2007) Lacrimo-Auriculo-Dento-Digital Syndrome is caused by reduced activity of the Fibroblast Growth Factor 10 (FGF10)-FGF Receptor. Mol. Cell. Biol. 27 (19):6903-6912.  

    Ravid O, Shams I, Ben-Califa N, Nevo E, Avivi A, and Neumann D. (2007) An extracellular region of the erythropoietin receptor of the subterranean blind mole rat Spalax enhances receptor maturation. Proc. Natl. Acad. Sci. USA, 104:14360-14363.

    Shams I, Avivi A, and Nevo E. (2005) Oxygen and carbon-dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-hypercapnic stresses. Comp. Biochem. Physiol. 142(3):376-382.  

    Shams I, Nevo E, and Avivi A. (2005) Erythropoietin receptor spliced forms differentially expressed in blind subterranean mole rats. FASEB J. 19(12):1749-1751.

     Avivi A, Shams I, Joel A, Lache O,  Levy AP, and Nevo E. (2005) Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat. FASEB J. 19:1314-1316.  

    Shams I, Nevo E, and Avivi A. (2005) Ontogenetic expression of erythropoietin and hypoxia-inducible factor-1 alpha genes in subterranean blind mole rats. FASEB 19:307-309.

    Shams I, Avivi A, and Nevo E. (2004) Hypoxic stress tolerance of the blind subterranean mole rat: Expression of erythropoietin and hypoxia-inducible factor 1a. Proc. Natl. Acad. Sci. USA, 101: 9698-9703.

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